Grifulvin V
Grifulvin V is an oral antifungal medication containing microsize griseofulvin. It works by inhibiting fungal cell mitosis (cell division) by disrupting mitotic spindle structures. It binds specifically to keratin in keratin precursor cells, making the newly formed skin, hair, and nails resistant to fungal invasion.
Dosage by Body Weight
Adult dosage is typically 500 mg to 1,000 mg daily in single or divided doses, depending on the severity and site of infection. Pediatric dosage is generally calculated by body weight (approximately 10 mg/kg daily). Grifulvin V must be taken with a fatty meal (such as whole milk or ice cream) to ensure proper absorption.
- Body Weight
- Below 5 kg
- Dose
- Not routinely recommended
- Frequency
- Use only if prescribed by a physician
- Tracking Notes
- Safety and effectiveness have not been established in infants and pediatric patients weighing less than 5 kg.
- Body Weight
- 5-7 kg
- Dose
- 50 mg to 70 mg daily (approx. 2 mL to 2.8 mL of 125mg/5mL suspension)
- Frequency
- Once daily or divided into two doses
- Tracking Notes
- Administer with a high-fat meal to maximize absorption. Duration of treatment depends on the infection site.
- Body Weight
- 8-10 kg
- Dose
- 80 mg to 100 mg daily (approx. 3.2 mL to 4 mL of 125mg/5mL suspension)
- Frequency
- Once daily or divided into two doses
- Tracking Notes
- Ensure complete compliance with the full course of therapy, even if symptoms resolve earlier.
- Body Weight
- 11-15 kg
- Dose
- 110 mg to 150 mg daily (approx. 4.4 mL to 6 mL of 125mg/5mL suspension)
- Frequency
- Once daily or divided into two doses
- Tracking Notes
- Avoid prolonged exposure to direct sunlight or ultraviolet light as griseofulvin can cause photosensitivity.
- Body Weight
- 16-20 kg
- Dose
- 160 mg to 200 mg daily (approx. 6.4 mL to 8 mL of 125mg/5mL suspension)
- Frequency
- Once daily or divided into two doses
- Tracking Notes
- Periodic monitoring of organ system functions, including renal, hepatic, and hematopoietic systems, should be done during prolonged therapy.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routinely recommended | Use only if prescribed by a physician | Safety and effectiveness have not been established in infants and pediatric patients weighing less than 5 kg. |
| 5-7 kg | 50 mg to 70 mg daily (approx. 2 mL to 2.8 mL of 125mg/5mL suspension) | Once daily or divided into two doses | Administer with a high-fat meal to maximize absorption. Duration of treatment depends on the infection site. |
| 8-10 kg | 80 mg to 100 mg daily (approx. 3.2 mL to 4 mL of 125mg/5mL suspension) | Once daily or divided into two doses | Ensure complete compliance with the full course of therapy, even if symptoms resolve earlier. |
| 11-15 kg | 110 mg to 150 mg daily (approx. 4.4 mL to 6 mL of 125mg/5mL suspension) | Once daily or divided into two doses | Avoid prolonged exposure to direct sunlight or ultraviolet light as griseofulvin can cause photosensitivity. |
| 16-20 kg | 160 mg to 200 mg daily (approx. 6.4 mL to 8 mL of 125mg/5mL suspension) | Once daily or divided into two doses | Periodic monitoring of organ system functions, including renal, hepatic, and hematopoietic systems, should be done during prolonged therapy. |
Formulation
Purpose
Treatment of fungal infections of the skin, hair, and nails (such as tinea capitis, tinea corporis, tinea cruris, tinea pedis, and tinea unguium) that do not respond to topical therapy.
Generic Name
Griseofulvin microsizeScheduled Drug
No. This medicine is generally not treated as a scheduled/prescription-only drug in common consumer references, but local rules may vary.